烟碱型乙酰胆碱受体A2(神经型)抗体简介

英文名称    CHRNA2(neuronal)    
中文名称    烟碱型乙酰胆碱受体A2(神经型)抗体    
别    名    Nicotinic-Acetylcholine receptor; Chrna2; ACHR; CHRNA2; neuronal acetylcholine receptor subunit alpha-2 precursor; Acra-2; Acra2; BC011490; MGC18795; ACHA2_HUMAN; Cholinergic receptor nicotinic alpha 2; Neuronal acetylcholine receptor protein subunit alpha 2; Neuronal acetylcholine receptor subunit alpha-2.    
说 明 书    0.1ml  0.2ml      
研究领域    细胞生物  免疫学  神经生物学  通道蛋白  细胞膜受体      
抗体来源    Rabbit    
克隆类型    Polyclonal    
交叉反应    Human, Mouse, Rat, Dog, Rabbit,     
产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 烟碱型乙酰胆碱受体A2(神经型)抗体（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    
分 子 量    57kDa    
性    状    Lyophilized or Liquid    
浓    度    1mg/1ml    
免 疫 原    KLH conjugated synthetic peptide derived from human CHRNA2    
亚    型    IgG    
纯化方法    affinity purified by Protein A    
储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    
保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

烟碱型乙酰胆碱受体A2(神经型)抗体产品介绍    background:
Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This gene encodes an alpha subunit that is widely expressed in the brain. The proposed structure for nAChR subunits is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. Mutations in this gene cause autosomal dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide polymorphisms (SNPs) in this gene have been associated with nicotine dependence. [provided by RefSeq].

Function:

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.