二肽基肽酶10抗体详细说明书

英文名称    DPP10    
中文名称    二肽基肽酶10抗体    
别    名    Dipeptidyl peptidase 10; Dipeptidyl peptidase 10 non functional; Dipeptidyl peptidase IV related protein 3; Dipeptidyl peptidase IV-related protein 3; Dipeptidyl peptidase like protein 2; Dipeptidyl peptidase X; Dipeptidyl peptidase-like protein 2; Dipeptidylpeptidase 10; DPL 2; DPL2; DPP 10; DPP X; Dpp10; DPP10_HUMAN; DPPY; DPRP 3; DPRP-3; DPRP3; Inactive dipeptidyl peptidase 10; KIAA1492.         
研究领域    肿瘤  细胞生物  信号转导  糖尿病  泛素      
抗体来源    Rabbit    
克隆类型    Polyclonal    
交叉反应    Human, Mouse, Rat, Horse,     
产品应用    WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 二肽基肽酶10抗体（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    
分 子 量    91kDa    
细胞定位    细胞膜     
性    状    Lyophilized or Liquid    
浓    度    1mg/1ml    
免 疫 原    KLH conjugated synthetic peptide derived from human DPP10    
亚    型    IgG    
纯化方法    affinity purified by Protein A    
储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    
保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

二肽基肽酶10抗体产品介绍 background:

Dipeptidyl peptidases (DPPs) mediate regulatory activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. DPPs have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. DPPs can bind specific voltage-gated potassium channels and alter their expression and biophysical properties and may also influence T cells. DPP proteins include DPRP1, DPRP2, DPP3, DPP7, DPP10, DPPX and CD26. DPP10 (dipeptidyl-peptidase 10), also known as DPRP3 (dipeptidyl peptidase IV-related protein 3), DPL2 or DPPY, is a non-functional dipeptidyl peptidase which can bind to the potassium channels KV4.1 and KV4.2. It is a single-pass type II membrane protein expressed in spinal cord, adrenal glands, pancreas and brain tissues and may act as a modulator for cell surface expression and activity of KV4.1 and KV4.2.

Function:
Has no dipeptidyl aminopeptidase activity. May modulate cell surface expression and activity of the potassium channels KCND1 and KCND2.

Subunit:
May form oligomers. Interacts with KCND1 (Probable). Interacts with KCND2.

Subcellular Location:
Membrane.

Tissue Specificity:
Found in serum, T-cells and brain (at protein level). Expressed in brain, pancreas, spinal cord and adrenal glands.

Post-translational modifications:
N-glycosylated.