双特异性磷酸酶2抗体应用说明

英文名称    DUSP2   

中文名称    双特异性磷酸酶2抗体   

别    名    Dual specificity phosphatase 2; Dual specificity protein phosphatase 2; Dual specificity protein phosphatase PAC 1; DUSP 2; PAC 1; PAC1; Serine/threonine specific protein phosphatase; DUS2_HUMAN.   

供应商      远慕生物   

研究领域    细胞生物  信号转导  细胞凋亡  细胞周期蛋白  转录调节因子  激酶和磷酸酶  表观遗传学     

抗体来源    Rabbit   

克隆类型    Polyclonal   

交叉反应    Human, Mouse, Rat, Dog, Cow, Horse, Sheep,    

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 双特异性磷酸酶2抗体（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.   

分 子 量    34kDa   

细胞定位    细胞核    

性    状    Lyophilized or Liquid   

浓    度    1mg/1ml   

免 疫 原    KLH conjugated synthetic peptide derived from human DUSP2   

亚    型    IgG   

纯化方法    affinity purified by Protein A   

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4   

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.   

双特异性磷酸酶2抗体产品介绍    background:

DUSP2 is a dual-specific thr/tyr phosphatase that is a physiologically relevant MAP kinase phosphatase. The gene is located on 2q11.2-q11 and contains 4 exons that span approximately 2.3kb. Under specific stress conditions, p53 regulates transcription of PAC1 through a new p53-binding site, and that PAC1 is necessary and sufficient for p53-mediated apoptosis.

Function:
Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.

Subcellular Location:
Nucleus.

Tissue Specificity:
Expressed in hematopoietic tissues.

Similarity:
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Contains 1 rhodanese domain.
Contains 1 tyrosine-protein phosphatase domain.

Database links:
UniProtKB/Swiss-Prot: Q05923.1

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.