丝氨酸/苏氨酸蛋白激酶17A/DAP凋亡诱导蛋白激酶1抗体简介

英文名称    DRAK1   

中文名称    丝氨酸/苏氨酸蛋白激酶17A/DAP凋亡诱导蛋白激酶1抗体   

别    名    DAP kinase-related apoptosis-inducing protein kinase 1; death-associated protein kinase-related 1; EC 2.7.11.1; Serine / threonine kinase 17a death associated protein kinase related 1; Serine/threonine kinase 17a; Serine/threonine protein kinase 17a; STK17 A; STK17A; ST17A_HUMAN.   

供 应 商    远慕生物    

研究领域    细胞生物  信号转导  细胞凋亡  激酶和磷酸酶     

抗体来源    Rabbit   

克隆类型    Polyclonal   

交叉反应    Human, Mouse, Rat, Chicken, Rabbit,    

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 丝氨酸/苏氨酸蛋白激酶17A/DAP凋亡诱导蛋白激酶1抗体（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.   

分 子 量    50kDa   

细胞定位    细胞核    

性    状    Lyophilized or Liquid   

浓    度    1mg/1ml   

免 疫 原    KLH conjugated synthetic peptide derived from human DRAK1/STK17A   

亚    型    IgG   

纯化方法    affinity purified by Protein A   

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4   

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.   

丝氨酸/苏氨酸蛋白激酶17A/DAP凋亡诱导蛋白激酶1抗体产品介绍    background:

DRAK1 (DAP kinase-related apoptosis-inducing protein kinase 1) is a novel member of the ser/thr protein kinase family, which mediate apoptosis through their catalytic activities. The full-length cDNA encodes a deduced 414-amino acid protein with a molecular mass of 46.56 kD. DRAKs contain an N-terminal kinase domain and a C-terminal regulation domain. DRAK1 messenger RNA appears to be ubiquitously expressed in human tissues. Overexpression of DRAK1 induces apoptosis. It has been shown in vitro that DRAK1 is capable of autophosphorylation and of phosphorylating the myosin light chain as an exogenous substrate, and that the noncatalytic C terminus is crucial for full kinase activity.

Function:
Acts as a positive regulator of apoptosis. Also acts as a regulator of cellular reactive oxygen species.

Subcellular Location:
Nucleus.

Tissue Specificity:
Highly expressed in placenta. Lower levels in heart, lung, skeletal muscle, kidney and pancreas.

Post-translational modifications:
Autophosphorylated.

Similarity:
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily.
Contains 1 protein kinase domain.