中文名称    E1A样分化抑制因子3抗体    

英文名称    EID3    

别    名    E1A-like inhibitor of differentiation 3; EID 3; EID-1-like inhibitor of differentiation 3; EID-3; EID3; EID3_HUMAN; EP300 interacting inhibitor of differentiation 3; EP300-interacting inhibitor of differentiation 3; Non-SMC element 4, S. cerevisiae, homolog of, B; NSE4B; NSMCE4B.    

供 应 商    远慕生物

研究领域    细胞生物  信号转导  细胞周期蛋白  转录调节因子  表观遗传学      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Cow, Horse, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 E1A样分化抑制因子3抗体（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    38kDa    

细胞定位    细胞核 细胞浆     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human EID3    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

E1A样分化抑制因子3抗体产品介绍    background:

Act as a repressor of nuclear receptor-dependent transcription possibly by interfering with CREBBP-dependent coactivation. May function as a coinhibitor of other CREBBP/EP300-dependent transcription factors.Tissue specificity: Highly expressed in testis.

Function:
Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components.
Acts as a repressor of nuclear receptor-dependent transcription possibly by interfering with CREBBP-dependent coactivation. May function as a coinhibitor of other CREBBP/EP300-dependent transcription factors.

Subunit:
Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3 and NDNL2; EID3 seems to be a testis-specific subunit. NSMCE1, NSMCE4A or EID3 and NDNL2 probably form a subcomplex that bridges the head domains of the SMC5:SMC6 heterodimer. Homodimer, and heterodimer with EID2 (By similarity). Interacts with the C-terminal region of CREBBP.

Subcellular Location:
Nucleus. Cytoplasm. Chromosome, telomere (Probable). Note=May shuttle between nucleus and cytoplasm.

Tissue Specificity:
Highly expressed in testis.

Similarity:
Belongs to the NSE4 family.

Gene ID:
493861

Database links:

Entrez Gene: 493861 Human

Entrez Gene: 66341 Mouse

Entrez Gene: 691688 Rat

Omim: 612986 Human

SwissProt: Q8N140 Human

SwissProt: Q3V124 Mouse

SwissProt: Q4V8G2 Rat

Unigene: 659857 Human

Unigene: 443284 Mouse

Unigene: 206488 Rat


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.