索引：外生性骨疣样蛋白2抗体研究方法

中文名称    外生性骨疣样蛋白2抗体    

英文名称    EXTL2    

别    名    Alpha 1 4 N acetylhexosaminyltransferase EXTL2; Alpha GalNAcT EXTL2; Exostoses (multiple) like 2; Exostoses multiple like 2; Exostosin like 2; EXT L2; EXT related protein 2; EXTL 2; EXTR 2; EXTR2; Glucuronyl galactosyl proteoglycan 4 alpha N acetylglucosaminyltransferase; Multiple exostoses like 2; Processed exostosin like 2; EXTL2_HUMAN.    

供 应 商    远慕生物

研究领域    肿瘤  免疫学  信号转导  细胞骨架      

抗体来源    Rabbit    

克隆类型    Polyclonal    

交叉反应    Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, Sheep,     

产品应用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 外生性骨疣样蛋白2抗体（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    37kDa    

细胞定位    细胞浆 细胞膜 分泌型蛋白     

性    状    Lyophilized or Liquid    

浓    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human EXTL    

亚    型    IgG    

纯化方法    affinity purified by Protein A    

储 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存条件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

外生性骨疣样蛋白2抗体产品介绍    background:

EXTL2 is a glycosyltransferase required for the biosynthesis of heparan-sulfate and is responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains.

Function:
Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains.

Subcellular Location:
Endoplasmic reticulum membrane; Single-pass type II membrane protein .
Processed exostosin-like 2: Secreted. Note=A soluble form is found in the serum.

Tissue Specificity:
Ubiquitous.

Post-translational modifications:
The soluble form derives from the membrane form by proteolytic processing.

Similarity:
Belongs to the glycosyltransferase 47 family.

Gene ID:
BC045681

Database links:

Entrez Gene: 2135 Human

Entrez Gene: 58193 Mouse

GenBank: BC045681 Human

Omim: 602411 Human

SwissProt: Q9UBQ6 Human

SwissProt: Q9ES89 Mouse

Unigene: 357637 Human


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.