RAS相关抑细胞生长蛋白1抗体说明书

中文名称  RAS相关抑细胞生长蛋白1抗体
别    名  Di Ras1; DIRAS family GTP binding RAS like 1; Distinct subgroup of the Ras family member 1; GBTS1; GTP binding protein Di Ras1; Ras related inhibitor of cell growth; RIG; Rig protein; Small GTP binding tumor suppressor 1.
浓    度  1mg/1ml
规 格  0.2ml/200μg          
抗体来源  Rabbit  
克隆类型  polyclonal
交叉反应  Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse   
产品类型  一抗    
研究领域  肿瘤 细胞生物 信号转导 转录调节因子 G蛋白偶联受体  
蛋白分子量  predicted molecular weight: 22kDa
性    状  Lyophilized or Liquid
免 疫 原  KLH conjugated synthetic peptide derived from human DIRAS1
亚    型  IgG
纯化方法  affinity purified by Protein A
储 存 液  0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
产品应用   WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500
（石蜡切片需做抗原修复）
 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user.  
保存条件  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note  This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

RAS相关抑细胞生长蛋白1抗体产品介绍 The three human RAS genes encode highly related 188 to 189 amino acid proteins, designated H-Ras, N-Ras and K-Ras4A and K-Ras4B (the two K-Ras proteins arise from alternative gene splicing). Ras proteins function as binary molecular switches that control intracellular signaling networks. Ras-regulated signal pathways control such processes as actin cytoskeletal integrity, proliferation, differentiation, cell adhesion, apoptosis, and cell migration. Ras and ras-related proteins are often deregulated in cancers, leading to increased invasion and metastasis, and decreased apoptosis. DIRAS1 displays low GTPase activity and exists predominantly in the GTP-bound form. It is highly expressed in heart and brain.
Function : Displays low GTPase activity and exist predominantly in the GTP-bound form.
Subcellular Location : Cell membrane; Lipid-anchor; Cytoplasmic side (Potential).
Tissue Specificity : Highly expressed in heart and brain.
Similarity : Belongs to the small GTPase superfamily. Di-Ras family.
Database links : UniProtKB/Swiss-Prot: O95057.1